Our Vision

Using stem cell derived “miniature organs in a dish” as revolutionary platforms to understand disease progression, improve drug development, revolutionize personalized medicine, and ultimately to establish novel therapeutics for organ regeneration.

Mini Heart in a Dish

 

Capillary Network in a Dish

 

Human Stem Cell Derived Vasculature

 

Recent Work

The overarching goal of the Gu lab is to develop novel therapy for the regeneration of heart, lung, and vasculature in patients with congenital cardiac and pulmonary defects. Towards this goal, the Gu lab conducts translational and interdisciplinary research using patient-specific induced pluripotent stem cells (iPSCs), vessel and lung organoids, animal models, single cell RNA/ATAC sequencing, and spatial transcriptomics for disease modeling and high-throughput drug screening. 

Vessel Organoid for Regenerative Medicine

Vessel Organoid for Regenerative Medicine
Human Cell Atlas in Heart, Lung, and Vasculature

Human Cell Atlas in Heart, Lung, and Vasculature
Modeling Human Disease in a Dish

Modeling Human Disease in a Dish
Drug Development and Precision Medicine

Drug Development and Precision Medicine